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KMID : 0613820070170101361
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Journal of Life Science
2007 Volume.17 No. 10 p.1361 ~ p.1367
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A Protein Kinase-A Inhibitor, KT5720, Suppressed Cytopathic Effect Caused by Vesicular Stomatitis Virus
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Kim Young-Sook
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Abstract
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I investigated the effect of KT5720, an inhibitor of protein kinase A, on the vesicular stomatitis virus (VSV) infection in BHK- 21cell cultures . The virus inducted cytopathic effect (CPE) was almost completely suppressed by KT5720 at 5uM. The inhibitor, however, did not affect replication of the virus nor the synthesis of viral macromolecules. KT5720, did not block the cytoskeletal disruption, while the cell rounding was suppressed. And, the KT5720-sensitive function may be involved in developing the VSV-induced CPE, but not essential for the virus replications.
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KEYWORD
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Vesicular stomatitis virus (VSV), KT5720, cytopathic effect (CPE)
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